席廣民

2022年07月12日 23:27 點擊：[]

基本情況

姓名：席廣民性別：男

學位：博士專業(yè)：生物化學與分子生物學

電話: 15725123910 E-mail: 475810355@qq.com

承擔課題

項目編號	項目名稱	位次	計劃類別	起止年月	完成或進展情況
ZR2013CL018	自噬在前列腺癌發(fā)生及治療中的作用研究	負責人	山東省自然科學基金	2013.01-2015.12	完成
J14LE52	survivin基因在紫杉醇誘導自噬過程中的作用研究	負責人	山東省教育廳科研發(fā)展計劃	2014.01-2015.12	完成
J08LG63	Akt基因在膠質瘤中的表達及其與放射敏感性關系的研究	負責人	山東省教育廳科研發(fā)展計劃	2008.5-2010.10	完成

申請者簡介

主要研究方向為細胞焦亡執(zhí)行蛋白GSDMD在T細胞殺傷腫瘤細胞中的作用及機制研究，腫瘤免疫耐受的分子機制研究。主持省廳級課題多項，發(fā)表SCI文章十幾篇。

發(fā)表文章

1.Zhan P#, Xi GM#, Zhang B, Wu Y, Liu HB, Liu YF, Xu WJ, Zhu Q, Cai F, Zhou ZJ, Miu YY, Wang XX, Jin JJ, Li Q, Lv TF, Song Y.NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma.

J Cell Mol Med. 2017,21(4):665-676.(IF=4.49)

2. Zhan P, Zhang B, Xi GM, Wu Y, Liu HB, Liu YF, Xu WJ, Zhu QQ, Cai F, Zhou ZJ, Miu YY, Wang XX, Jin JJ, Li Q, Qian LP, Lv TF, Song Y.PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway.Mol Cancer. 2017,16(1):108.(IF=6.2)

3. Zhan P, Xi GM, Liu HB, Liu YF, Xu WJ, Zhu Q, Zhou ZJ, Miao YY, Wang XX, Jin JJ, Lv TF, Song Y.Protein regulator of cytokinesis-1 expression: prognostic value in lung squamous cell carcinoma patients.J Thorac Dis. 2017,9(7):2054-2060.

4. Wan B, Xu WJ, Xu WN, Zhan P, Wu GN, Jin JJ, Xi GM, Yin JT, Zhang H, Chen YK, Miao YY, Wang XX, Xu YK, Lv TF, Song Y.Plasma long noncoding RNA IL-7R as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome.Clin Respir J. 2017 Sep 29. doi: 10.1111/crj.12717.

5.Xi G,Wang M, Sun B, Shaikh AS, Liu Y, Wang W, Lou H, Yuan H.Targeting autophagy augments the activity of DHA-E3 to overcome p-gp mediated multi-drug resistance.Biomed Pharmacother. 2016,84:1610-1616.

6.Xi G,Hu X,Wu B,Jiang H,Young CY,Pang Y,Yuan H.Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells.Cancer Lett.2011 Apr 19. (IF=6.375)

7.Xi GM, Sun B, Jiang HH, Kong F, Yuan HQ, Lou HX.Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. Bioorg Med Chem. 2010 Sep 15;18(18):6725-33 (IF=2.93)

8.Guo DX,Xiang F,Wang XN,Yuan HQ,Xi GM,Wang YY,Yu WT,Lou HX. Labdane diterpenoids and highly methoxylated bibenzyls from the liverwort Frullania inouei.Phytochemistry.2010 Sep;71(13):1573-8.

9.Sun B,Yuan HQ,Xi GM,Ma YD,Lou HX. Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives.Bioorg Med Chem.2009 Jul 15;17(14):4981-9.

10.Niu RF,Zhang L,Xi GM,Wei XY,Yang Y,Shi YR,Hao XS. Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma.J Exp Clin Cancer Res.2007 Sep;26(3):385-94.

11.Gangmin Xi Lin Zhang Zhongli Zhan Lihua Zhang Xiyin Wei Yi Yang Yurong Shi Fei Zhang Ruifang Niu. The Effect of Twist Expression on Angiogenesis in Hepatocellular Carcinoma。Chinese Journal of Clinical Oncology.2006(6): 413-418.