段廣有

個人簡介

段廣有，教授，自2016年9月起任職于齊魯師范學院生命科學學院，目前擔任齊魯師范學院山東省首批優(yōu)勢學科人才團隊學術帶頭人，同時兼任齊魯師范學院歐美同學會（留學人員聯(lián)誼會）副秘書長等職。

段博士學術專業(yè)為生物信息學，于2014年初獲得德國馬克思普朗克研究所（分子植物生理所，MPIMP）生物信息學博士學位，之后在歐洲分子生物學實驗室（EMBL）從事博士后研究工作，已從事生物信息學相關研發(fā)工作十余年；段博士的研究目標是利用生物學、計算機、數(shù)學、統(tǒng)計學等交叉學科方法解決生物、農(nóng)學或者醫(yī)學等相關問題，已在Nucleic Acids Research, PLoS Computational Biology, Plant Cell, Scientific Reports等國際刊物上發(fā)表多篇論文，并且擔任BMC Bioinformatics，Journal of Plant Pathology and Microbiology等學術雜志的審稿人。主講生物信息學、圖論等課程。

研究方向

1.系統(tǒng)生物學

2. 結構生物信息學

主持和參與課題

1.山東省高等學校優(yōu)勢學科人才團隊培育計劃（生物質品種改良團隊）(魯教人字【2015】18號)，山東省教育廳、山東省財政廳，主持，2015年11月~2020年11月，600萬；

2.胸腺上皮細胞中異位基因表達的DNA甲基化調(diào)控機制研究（31700787），國家自然科學基金委，參與，2018年1月~2020年12月，24萬。

發(fā)表論文

1.Li, Xin, Guangyou Duan, Wei Zhang, Jinsong Shi, Jiayuan Chen, Shunmei Chen, Shan Gao, and Jishou Ruan. A Furin Cleavage Site Was Discovered in the S Protein of the 201 9 Novel Coronavirus. Chinese Journal of Bioinformatics 2020.

2.Gao, Li, Yong Jie Yang, En Qi Li,Guang You Duan, Xiang Dong Li, Jia Ning Mao, Dong Yan Zhang, and Ye Li. Sgne Expression Profiling of Peripheral Blood Mononuclear Cells in Young Male Trampolinists.Acta Medica Mediterranea2019. 35(5):2693–2701.

3.Heyneke, Elmien, Mutsumi Watanabe, Alexander Erban,Guangyou Duan, Peter Buchner, Dirk Walther, Joachim Kopka, Malcolm John Hawkesford, and Rainer Hoefgen. Effect of Senescence Phenotypes and Nitrate Availability on Wheat Leaf Metabolome during Grain Filling.Agronomy2019. 9(6).

4.Feng Cui, Na Sui,Guangyou Duan, Yiyang Liu, Yan Han, Shanshan Liu, Shubo Wan, and Guowei Li. Identification of metabolites and transcripts involved in salt stress and recovery in peanut.Frontiers in Plant Science2018, 9: 217

5.Shaochuan Shi,Guangyou Duan^#, Dandan Li, Jie Wu, Xintong Liu, Bo Hong, Mingfang Yi, and Zhao Zhang. Two-dimensional analysis provides molecular insight into flower scent ofLilium ‘Siberia’.Scientific Reports2018. 8 (1): 5352

6.Sukackaite, Rasa, Daniela Cornacchia, Malene Ringkj?bing Jensen, Philippe J Mas, Martin Blackledge, Elin Enervald,Guangyou Duan, Tania Auchynnikava, Maja K?hn, Darren J Hart, Sara B C Buonomo. Mouse Rif1 Is a Regulatory Subunit of Protein Phosphatase 1 (PP1).Scientific Reports2017, 7 (1): 2119

7.Hoeger, Birgit, Pablo Rios, Anna Berteotti, Bernhard Hoermann,Guangyou Duan, and Maja K?hn. Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL-3.ACS Omega2017. 2(12):9171–80.

8.Heyneke, Elmien, Mutsumi Watanabe, Alexander Erban,Guangyou Duan, Peter Buchner, Dirk Walther, Joachim Kopka, Malcolm J. Hawkesford, and Rainer Hoefgen. Characterization of the Wheat Leaf Metabolome during Grain Filling and under Varied N-Supply.Frontiers in Plant Science2017. 8:2048.

9.Karolina Pavic,Guangyou Duan, Maja Koehn. VHR/DUSP3 phosphatase: structure, function and regulation.The FEBS Journal2015, 282(10):1871-1890

10.Guangyou Duan, Dirk Walther. The roles of post-translational modifications in the context of protein interaction networks.PLoS Computational Biology2015, 11(2):e1004049

11.Guangyou Duan, Dirk Walther. Computational phosphorylation network reconstruction: methods and resources.Methods in Molecular Biology2015, 1306: 177-94

12.Guangyou Duan^#, Xun Li, Maja Koehn. The human DEPhOsphorylation database DEPOD: a 2015 update.Nucleic Acids Research2015, 43: D531-D535

13.Ning Zhang, Shan Gao,Guangyou Duan, Yuanming Feng, Jishou Ruan, Tao Zhang. SRD: a universal software tool for DNA/Protein sequence relationship visualization based on undirected graphs.Current Bioinformatics2015, 10: 69-78

14.Guangyou Duan^*. Systems Biology-Based Study for Plant and Phytopathogen Interaction.Plant Pathology & Microbiology2014, 4:e106

15.Umesh Prasad Yadav, Alexander Ivakov, Regina Feil,Guang You Duan, Dirk Walther, Patrick Giavalisco, Maria Piques, Petronia Carillo, Hans-Michael Hubberten, Mark Stitt, John Edward Lunn. The sucrose-Tre6P nexus: specificity and mechanisms of sucrose signalling by trehalose 6-phosphate.Journal of Experimental Botany2014,65(4):1051-68.

16.Guangyou Duan^*, Dirk Walther, Waltraud Schulze. Reconstruction and analysis of nutrient-induced phosphorylation networks in Arabidopsis thaliana.Frontiers in Plant Science2013, 4: 540.

17.Ning Shao,Guang You Duan, Ralph Bock. A New Mediator of Singlet Oxygen Responses in Chlamydomonas and Arabidopsis Identified by a Luciferase-based Genetic Screen in Algal Cells.Plant Cell2013, 25(10): 4209-26.

18.Guangyou Duan^#, Christian Nils, Schwachtje Jens, Walther Dirk, Ebenh?h Oliver. The Metabolic Interplay between Plants and Phytopathogens.Metabolites 2013, 3 (1): 1-23.

19.Gao, Shan, Ning Zhang, Lei Zhang,Guang You Duan, and Tao Zhang. [The Human Variome Project and Its Progress].Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji2010. 32(11):1105–13.

20.Ning Zhang,Guangyou Duan, Shan Gao, Jishou Ruan, Tao Zhang. Prediction of the Parallel / Antiparallel Orientation of Beta-Strands Using Amino Acid Pairing Preferences and Support Vector Machines.Journal of Theoretical Biology2010, 263 (3): 360-8.

21.Shan Gao, Ning Zhang,Guang You Duan, Zhuo Yang, Ji Shou Ruan and Tao Zhang: Prediction of Function Changes Associated With Single Point Protein Mutations Using Support Vector Machines (SVMs).Human Mutation2009, 30 (8):1161-6.

22.Ning Zhang, Jishou Ruan,Guangyou Duan, Shan Gao and Tao Zhang: The interstrand amino acid pairs play a significant role in determining the parallel or antiparallel orientation of β-strands.Biochemical and Biophsical Research Communications2009, 386 (3): 537-543.